O'Fallon vs St. Louis: Physician Assistant Salary (2026)
Compare physician assistant salaries between O'Fallon, MO and St. Louis, MO. All figures are 2026 estimates projected from BLS 2025 data.
Side-by-Side Comparison
| Metric | O'Fallon, MO | St. Louis, MO |
|---|---|---|
| Median Salary | $140,161 | $140,639▲ |
| Hourly Rate | $67.39 | $67.61▲ |
| Entry Level (P10) | $99,560▲ | $80,197 |
| 25th Percentile | $121,209 | $128,199▲ |
| 75th Percentile | $168,493 | $170,168▲ |
| Top Earner (P90) | $202,341▲ | $176,636 |
| Total Employed | 22 | 1,260▲ |
Verdict
St. Louis, MO offers better overall compensation for physician assistants, winning 3 out of 4 metrics compared to O'Fallon.
The salary gap between O'Fallon and St. Louis is $478 (0.34%). St. Louis's median is +0.18% compared to the US national median of $140,391.
Salary Range Comparison
The full salary range (10th to 90th percentile) in O'Fallon spans $102,781,St. Louis spans $96,439. O'Fallon has a wider pay range, meaning more potential for high earners but also more variation.
Cost-of-Living Adjusted Comparison
After cost-of-living adjustment, O'Fallon ($156,430 effective) pays 5.76% more than St. Louis ($147,904 effective).
Cost-of-living adjustment: salary × (100 / CoL index). Index of 100 = national average.
Which City Is Right for You?
Choose O'Fallon if…
- ✓Better top-earner potential ($202,341)
- ✓Better purchasing power (CoL-adjusted: $156,430)
- ✓You prefer the Missouri area and lifestyle
Choose St. Louis if…
- ✓Higher median salary ($140,639/year)
- ✓Larger job market (1,260 employed)
- ✓You prefer the Missouri area and lifestyle
Historical Salary Growth Comparison
Based on BLS OEWS metropolitan area data, physician assistant salaries in O'Fallon grew 28.4% from 2024 to 2025, compared to 35.0% growth in St. Louis over the same period.
O'Fallon, MO
$105,671 (2024) → $135,657 (2025)
St. Louis, MO
$100,810 (2019) → $136,120 (2025)
View Full Salary Data
O'Fallon, MO
St. Louis, MO
Frequently Asked Questions
Which city pays physician assistants more: O'Fallon or St. Louis?
What is the hourly rate difference between O'Fallon and St. Louis?
Should I relocate from O'Fallon to St. Louis as a physician assistant?
What do entry-level physician assistants earn in O'Fallon vs St. Louis?
Related Comparisons
Written by Jessica Tran, MPAS, PA-C
Career Analyst
Jessica has 10 years of experience as a physician assistant. Her specialty is cardiology in an outpatient setting.
Methodology & Data Source
All salary figures are 2026 projections based on BLS OEWS May 2025 data. A 3.32% CAGR (derived from 6-year national BLS trends) was applied to estimate current compensation. Cost-of-living adjustments use BEA Regional Price Parity data. Actual salaries vary by employer, certifications, and experience.
Data Sources & Methodology
Source: BLS, OEWS , released .
Compiled and verified by Jessica Tran, MPAS, PA-C, a licensed physician assistant with 10+ years of clinical experience. · View source data at BLS.gov